Enpp1 deficiency caused chondrocyte apoptosis by inhibiting AMPK signaling pathway

Enpp1 deficiency caused chondrocyte apoptosis by inhibiting AMPK signaling pathway

Abstract Objective and background The deficiency of ectonucleotide pyrophosphatase/phosphodiesterase 1 (Enpp1) causes the phenotype similar to knee osteoarthritis (OA). However, the molecular mechanism is poorly understood. Method The global deletion of Enpp1 (Enpp1−/−) mice was created to analyze t...

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Bibliographic Details
Main Authors: Zhiqiang Gao, Qiang Wang, Kai Guo, Xinhua Li, Yufeng Huang
Format: Article
Language:English
Published: BMC 2023-06-01
Series:Journal of Orthopaedic Surgery and Research
Subjects:
Enpp1
Osteoarthritis
Apoptosis
AMPK
AICAR
Online Access:https://doi.org/10.1186/s13018-023-03923-1

Internet

https://doi.org/10.1186/s13018-023-03923-1

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