Tyrosine kinase inhibitors relax pulmonary arteries in human and murine precision-cut lung slices

Tyrosine kinase inhibitors relax pulmonary arteries in human and murine precision-cut lung slices

Abstract Background Tyrosine kinase inhibitors (TKIs) inhibit the platelet derived growth factor receptor (PDGFR) and gain increasing significance in the therapy of proliferative diseases, e.g. pulmonary arterial hypertension (PAH). Moreover, TKIs relax pulmonary vessels of rats and guinea pigs. So...

Full description

Bibliographic Details
Main Authors: Annette D. Rieg, Nina A. Bünting, Christian Cranen, Said Suleiman, Jan W. Spillner, Heike Schnöring, Thomas Schröder, Saskia von Stillfried, Till Braunschweig, Paul W. Manley, Gereon Schälte, Rolf Rossaint, Stefan Uhlig, Christian Martin
Format: Article
Language:English
Published: BMC 2019-06-01
Series:Respiratory Research
Subjects:
Tyrosine kinase inhibitors
Imatinib
Nilotinib
Pulmonary arteries
Pulmonary arterial hypertension
Online Access:http://link.springer.com/article/10.1186/s12931-019-1074-2

Internet

http://link.springer.com/article/10.1186/s12931-019-1074-2

Similar Items