PPAR-γ agonist pioglitazone improves semen quality and testicular histomorphometrics with partial reversal of hyperglycaemia in alloxan-induced diabetic rats
Objective: Chronic hyperglycaemia is associated with subfertility and infertility in male diabetic subjects, possible as a result of perturbed testicular antioxidant defence system. Recent evidence however shows that some testicular cells produce insulin and this raises the possibility of a role for...
Main Authors: | O.B. Akinola, O.O. Dosumu, S.A. Sanusi, T.F. Ajayi, T.H. Olajide |
---|---|
Format: | Article |
Language: | English |
Published: |
SpringerOpen
2015-12-01
|
Series: | Middle East Fertility Society Journal |
Subjects: | |
Online Access: | http://www.sciencedirect.com/science/article/pii/S1110569014200550 |
Similar Items
-
Pioglitazone abrogates testicular damage induced by testicular torsion/detorsion in rats
by: Nevertyty Mohamed Mahmoud, et al.
Published: (2019-08-01) -
Study of the effect of pioglitazone on testicular function after scrotal heat induced shock in the rat
Published: (2015-05-01) -
Pioglitazone enhances cisplatin’s impact on triple-negative breast cancer: Role of PPARγ in cell apoptosis
by: Qamraa Hamad Alqahtani, et al.
Published: (2024-05-01) -
The Pioglitazone Trek via Human PPAR Gamma: From Discovery to a Medicine at the FDA and Beyond
by: Pallavi R. Devchand, et al.
Published: (2018-10-01) -
Systemic Treatment with Pioglitazone Reverses Vision Loss in Preclinical Glaucoma Models
by: Huilan Zeng, et al.
Published: (2022-02-01)