A SARS-CoV-2 NSP7 homolog of a Treg epitope suppresses CD4+ and CD8+ T cell memory responses

A SARS-CoV-2 NSP7 homolog of a Treg epitope suppresses CD4+ and CD8+ T cell memory responses

Pathogens escape host defenses by T-cell epitope mutation or deletion (immune escape) and by simulating the appearance of human T cell epitopes (immune camouflage). We identified a highly conserved, human-like T cell epitope in non-structural protein 7 (NSP7) of SARS-CoV-2, RNA-dependent RNA polymer...

Full description

Bibliographic Details
Main Authors: S. M. Shahjahan Miah, Sandra Lelias, Andres H. Gutierrez, Mitchell McAllister, Christine M. Boyle, Lenny Moise, Anne S. De Groot
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-11-01
Series:Frontiers in Immunology
Subjects:
SARS-CoV-2
Tregitope
nsp7
tolerance
immunogenicity
immune camouflage
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1290688/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2023.1290688/full

Similar Items