Experimental and computational analysis of biased agonism on full-length and a C-terminally truncated adenosine A2A receptor

Experimental and computational analysis of biased agonism on full-length and a C-terminally truncated adenosine A2A receptor

Biased agonism, the ability of agonists to differentially activate downstream signaling pathways by stabilizing specific receptor conformations, is a key issue for G protein-coupled receptor (GPCR) signaling. The C-terminal domain might influence this functional selectivity of GPCRs as it engages G...

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Bibliographic Details
Main Authors: Gemma Navarro, Angel Gonzalez, Stefano Campanacci, Rafael Rivas-Santisteban, Irene Reyes-Resina, Nil Casajuana-Martin, Arnau Cordomí, Leonardo Pardo, Rafael Franco
Format: Article
Language:English
Published: Elsevier 2020-01-01
Series:Computational and Structural Biotechnology Journal
Subjects:
G protein coupled receptors
Adenosine A2A receptor
Functional selectivity
G protein binding
β-Arrestin recruitment
Molecular dynamic simulations
Online Access:http://www.sciencedirect.com/science/article/pii/S2001037020304128

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http://www.sciencedirect.com/science/article/pii/S2001037020304128

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