Adenoviral VEGF-B186R127S gene transfer induces angiogenesis and improves perfusion in ischemic heart

Adenoviral VEGF-B186R127S gene transfer induces angiogenesis and improves perfusion in ischemic heart

Summary: Vascular endothelial growth factor B (VEGF-B) is an interesting therapeutic candidate for coronary artery disease. However, it can also cause ventricular arrhythmias, potentially preventing its use in clinics. We cloned VEGF-B isoforms with different receptor binding profiles to clarify the...

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Bibliographic Details
Main Authors: Henna Korpela, Olli-Pekka Hätinen, Tiina Nieminen, Rahul Mallick, Pyry Toivanen, Jonna Airaksinen, Kaisa Valli, Mikko Hakulinen, Pekka Poutiainen, Jussi Nurro, Seppo Ylä-Herttuala
Format: Article
Language:English
Published: Elsevier 2021-12-01
Series:iScience
Subjects:
Cellular therapy
Biochemistry
Molecular biology
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004221015042

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http://www.sciencedirect.com/science/article/pii/S2589004221015042

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