DOT1L affects colorectal carcinogenesis via altering T cell subsets and oncogenic pathway

DOT1L affects colorectal carcinogenesis via altering T cell subsets and oncogenic pathway

Chronic inflammation and oncogenic pathway activation are key-contributing factors in colorectal cancer pathogenesis. However, colorectal intrinsic mechanisms linking these two factors in cancer development are poorly defined. Here, we show that intestinal epithelial cell (IEC)-specific deletion of...

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Bibliographic Details
Main Authors: Danfeng Sun, Weichao Wang, Fangfang Guo, Michael R. Pitter, Wan Du, Shuang Wei, Sara Grove, Linda Vatan, Yingxuan Chen, Ilona Kryczek, Eric R. Fearon, Jing-Yuan Fang, Weiping Zou
Format: Article
Language:English
Published: Taylor & Francis Group 2022-12-01
Series:OncoImmunology
Subjects:
DOT1L
H3K79me2
colorectal cancer
regulatory T cell
FOXP3
RORgt
Online Access:https://www.tandfonline.com/doi/10.1080/2162402X.2022.2052640

Internet

https://www.tandfonline.com/doi/10.1080/2162402X.2022.2052640

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