Leukotriene D4 Upregulates Oxidized Low-Density Lipoprotein Receptor 1 and CD36 to Enhance Oxidized LDL Uptake and Phagocytosis in Macrophages Through Cysteinyl Leukotriene Receptor 1

Leukotriene D4 Upregulates Oxidized Low-Density Lipoprotein Receptor 1 and CD36 to Enhance Oxidized LDL Uptake and Phagocytosis in Macrophages Through Cysteinyl Leukotriene Receptor 1

Endothelial permeability, leukocyte attachment, and unregulated oxidized LDL (oxLDL) uptake by macrophages leading to the formation of foam cells are all vital in the initiation and progression of atherosclerosis. During inflammation, several inflammatory mediators regulate this process through the...

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Bibliographic Details
Main Authors: Sabita Pokhrel, Ravindra Gudneppanavar, Lakshminarayan Reddy Teegala, Ernest Duah, Charles K. Thodeti, Sailaja Paruchuri
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-11-01
Series:Frontiers in Physiology
Subjects:
LTD4
CysLT1R
phagocytosis
oxLDL
CD36
OLR1
Online Access:https://www.frontiersin.org/articles/10.3389/fphys.2021.756450/full

Internet

https://www.frontiersin.org/articles/10.3389/fphys.2021.756450/full

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