Knockdown of long non-coding RNA PVT1 induces apoptosis of fibroblast-like synoviocytes through modulating miR-543-dependent SCUBE2 in rheumatoid arthritis

Knockdown of long non-coding RNA PVT1 induces apoptosis of fibroblast-like synoviocytes through modulating miR-543-dependent SCUBE2 in rheumatoid arthritis

Abstract Background Rheumatoid arthritis (RA), a kind of autoimmune disorder, is featured by many physical symptoms and proliferation of fibroblast-like synoviocytes (FLSs). The relevance of long non-coding RNAs (lncRNAs) in the progression of RA has been probed. Hence, the goal of this report was t...

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Bibliographic Details
Main Authors: Junxia Wang, Xianghui Kong, Haijian Hu, Shunfang Shi
Format: Article
Language:English
Published: BMC 2020-04-01
Series:Journal of Orthopaedic Surgery and Research
Subjects:
Long non-coding RNA PVT1
MicroRNA-543
SCUBE2
Rheumatoid arthritis
Synovial cells
Interleukin-1β
Online Access:http://link.springer.com/article/10.1186/s13018-020-01641-6

Internet

http://link.springer.com/article/10.1186/s13018-020-01641-6

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