Therapeutically engineered induced neural stem cells are tumour-homing and inhibit progression of glioblastoma
Neural stem cells have a tropism for glioblastoma. Here the authors employ fibroblasts directly reprogrammed into induced neural stem cells and loaded with cytotoxic molecules to migrate to xenotransplanted brain tumours in mice, achieving tumour shrinkage and prolonged survival.
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2016-02-01
|
| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/ncomms10593 |