Role of PLK1/NUMB/NOTCH in epithelial-mesenchymal transition in human melanoma
Abstract Polo-like kinase 1 (PLK1), a serine/threonine kinase, is overexpressed in melanoma and its expression has been associated with poor disease prognosis. PLK1 has been shown to interact with NUMB, a NOTCH antagonist. However, the exact role of PLK1, NUMB, and NOTCH signaling in epithelial-mese...
Main Authors: | , , , , , |
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Format: | Article |
Language: | English |
Published: |
Nature Portfolio
2024-01-01
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Series: | npj Precision Oncology |
Online Access: | https://doi.org/10.1038/s41698-023-00493-7 |