Role of PLK1/NUMB/NOTCH in epithelial-mesenchymal transition in human melanoma

Role of PLK1/NUMB/NOTCH in epithelial-mesenchymal transition in human melanoma

Abstract Polo-like kinase 1 (PLK1), a serine/threonine kinase, is overexpressed in melanoma and its expression has been associated with poor disease prognosis. PLK1 has been shown to interact with NUMB, a NOTCH antagonist. However, the exact role of PLK1, NUMB, and NOTCH signaling in epithelial-mese...

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Bibliographic Details
Main Authors: Gagan Chhabra, Chandra K. Singh, Mary A. Ndiaye, Shengqin Su, Carl A. Shirley, Nihal Ahmad
Format: Article
Language:English
Published: Nature Portfolio 2024-01-01
Series:npj Precision Oncology
Online Access:https://doi.org/10.1038/s41698-023-00493-7

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