Saracatinib, a Src Tyrosine Kinase Inhibitor, as a Disease Modifier in the Rat DFP Model: Sex Differences, Neurobehavior, Gliosis, Neurodegeneration, and Nitro-Oxidative Stress

Saracatinib, a Src Tyrosine Kinase Inhibitor, as a Disease Modifier in the Rat DFP Model: Sex Differences, Neurobehavior, Gliosis, Neurodegeneration, and Nitro-Oxidative Stress

Diisopropylfluorophosphate (DFP), an organophosphate nerve agent (OPNA), exposure causes status epilepticus (SE) and epileptogenesis. In this study, we tested the protective effects of saracatinib (AZD0530), a Src kinase inhibitor, in mixed-sex or male-only Sprague Dawley rats exposed to 4–5 mg/kg D...

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Bibliographic Details
Main Authors: Meghan Gage, Marson Putra, Logan Wachter, Kylie Dishman, Megan Gard, Crystal Gomez-Estrada, Thimmasettappa Thippeswamy
Format: Article
Language:English
Published: MDPI AG 2021-12-01
Series:Antioxidants
Subjects:
diisopropylfluorophosphate
saracatinib
Src family kinase
neuroinflammation
neurodegeneration
nitro-oxidative stressors
Online Access:https://www.mdpi.com/2076-3921/11/1/61

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https://www.mdpi.com/2076-3921/11/1/61

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