TGFβ Impairs HNF1α Functional Activity in Epithelial-to-Mesenchymal Transition Interfering With the Recruitment of CBP/p300 Acetyltransferases

TGFβ Impairs HNF1α Functional Activity in Epithelial-to-Mesenchymal Transition Interfering With the Recruitment of CBP/p300 Acetyltransferases

The cytokine transforming growth factor β (TGFβ) plays a crucial role in the induction of both epithelial-to-mesenchymal transition (EMT) program and fibro-cirrhotic process in the liver, where it contributes also to organ inflammation following several chronic injuries. All these pathological situa...

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Bibliographic Details
Main Authors: Francesca Bisceglia, Cecilia Battistelli, Valeria Noce, Claudia Montaldo, Agatino Zammataro, Raffaele Strippoli, Marco Tripodi, Laura Amicone, Alessandra Marchetti
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-08-01
Series:Frontiers in Pharmacology
Subjects:
HNF1α
TGFβ
CBP/p300
histone acetylation
EMT
fibrosis
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2019.00942/full

Internet

https://www.frontiersin.org/article/10.3389/fphar.2019.00942/full

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