Mechanisms of Androgen Receptor Agonist- and Antagonist-Mediated Cellular Senescence in Prostate Cancer

Mechanisms of Androgen Receptor Agonist- and Antagonist-Mediated Cellular Senescence in Prostate Cancer

The androgen receptor (AR) plays a leading role in the control of prostate cancer (PCa) growth. Interestingly, structurally different AR antagonists with distinct mechanisms of antagonism induce cell senescence, a mechanism that inhibits cell cycle progression, and thus seems to be a key cellular re...

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Bibliographic Details
Main Authors: Miriam Kokal, Kimia Mirzakhani, Thanakorn Pungsrinont, Aria Baniahmad
Format: Article
Language:English
Published: MDPI AG 2020-07-01
Series:Cancers
Subjects:
prostate cancer
cellular senescence
bipolar androgen therapy
antiandrogen
androgen receptor antagonist
supraphysiological androgen levels
Online Access:https://www.mdpi.com/2072-6694/12/7/1833

Internet

https://www.mdpi.com/2072-6694/12/7/1833

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