Cesin, a short natural variant of nisin, displays potent antimicrobial activity against major pathogens despite lacking two C-terminal macrocycles

Cesin, a short natural variant of nisin, displays potent antimicrobial activity against major pathogens despite lacking two C-terminal macrocycles

ABSTRACT Nisin is a widely used lantibiotic owing to its potent antimicrobial activity and its food-grade status. Its mode of action includes cell wall synthesis inhibition and pore formation, which are attributed to the lipid II binding and pore-forming domains, respectively. We discovered cesin, a...

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Bibliographic Details
Main Authors: Longcheng Guo, Joseph Wambui, Chenhui Wang, Francis Muchaamba, Maria Victoria Fernandez-Cantos, Jaap Broos, Taurai Tasara, Oscar P. Kuipers, Roger Stephan
Format: Article
Language:English
Published: American Society for Microbiology 2023-10-01
Series:Microbiology Spectrum
Subjects:
cesin
nisin
Clostridium estertheticum
bacteriocin
lipid II
Online Access:https://journals.asm.org/doi/10.1128/spectrum.05319-22

Internet

https://journals.asm.org/doi/10.1128/spectrum.05319-22

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