Immune complex-induced apoptosis and concurrent immune complex clearance are anti-inflammatory neutrophil functions

Abstract Persistent neutrophilic inflammation drives host damage in autoimmune diseases that are characterized by abundant immune complexes. Insoluble immune complexes (iICs) potently activate pro-inflammatory neutrophil effector functions. We and others have shown that iICs also promote resolution...

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Bibliographic Details
Main Authors: Utsa Karmakar, Julia Y. Chu, Kruthika Sundaram, Anne L. Astier, Hannah Garside, Carsten G. Hansen, Ian Dransfield, Sonja Vermeren
Format: Article
Language:English
Published: Nature Publishing Group 2021-03-01
Series:Cell Death and Disease
Online Access:https://doi.org/10.1038/s41419-021-03528-8