A Modified Basophil Activation Test for the Clinical Management of Immediate Hypersensitivity Reactions to Paclitaxel: A Proof-of-Concept Study

A Modified Basophil Activation Test for the Clinical Management of Immediate Hypersensitivity Reactions to Paclitaxel: A Proof-of-Concept Study

Immediate hypersensitivity reactions (iHSRs) to taxanes are observed in 6% and 4% of gynecologic and breast cancer patients, respectively. Drug desensitization is the only option, as no comparable alternative therapy is available. Surfactants in the taxane formulation have been implicated in the imm...

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Bibliographic Details
Main Authors: Marilena La Sorda, Marco Fossati, Rosalia Graffeo, Manuela Ferraironi, Maria Cristina De Rosa, Alexia Buzzonetti, Benedetta Righino, Nicole Zampetti, Andrea Fattorossi, Eleonora Nucera, Arianna Aruanno, Gabriella Ferrandina, Adriana Ionelia Apostol, Alessandro Buonomo, Giovanni Scambia, Maurizio Sanguinetti, Alessandra Battaglia
Format: Article
Language:English
Published: MDPI AG 2023-12-01
Series:Cancers
Subjects:
basophils
BAT
flow cytometry
hypersensitivity
MRGPRX2
platinum
Online Access:https://www.mdpi.com/2072-6694/15/24/5818

Internet

https://www.mdpi.com/2072-6694/15/24/5818

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