Failure of CD4 T-cells to respond to liver-derived antigen and to provide help to CD8 T-cells.

Failure of CD4 T-cells to respond to liver-derived antigen and to provide help to CD8 T-cells.

CD4 T-cell help is required for the induction of efficient CD8 T-cells responses and the generation of memory cells. Lack of CD4 T-cell help may contribute to an exhausted CD8 phenotype and viral persistence. Little is known about priming of CD4 T-cells by liver-derived antigen. We used TF-OVA mice...

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Bibliographic Details
Main Authors: Katja Derkow, Anja Müller, Ira Eickmeier, Daniel Seidel, Marcos Vicinius Rust Moreira, Nils Kruse, Katja Klugewitz, Justine Mintern, Bertram Wiedenmann, Eckart Schott
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3136477?pdf=render

Internet

http://europepmc.org/articles/PMC3136477?pdf=render

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