Model-Based Optimisation and Control Strategy for the Primary Drying Phase of a Lyophilisation Process

Model-Based Optimisation and Control Strategy for the Primary Drying Phase of a Lyophilisation Process

The standard operation of a batch freeze-dryer is protocol driven. All freeze-drying phases (i.e., freezing, primary and secondary drying) are programmed sequentially at fixed time points and within each phase critical process parameters (CPPs) are typically kept constant or linearly interpolated be...

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Bibliographic Details
Main Authors: Brecht Vanbillemont, Niels Nicolaï, Laurens Leys, Thomas De Beer
Format: Article
Language:English
Published: MDPI AG 2020-02-01
Series:Pharmaceutics
Subjects:
freeze-drying
supervisory process control
primary drying
dynamic design space
uncertainty analysis
Online Access:https://www.mdpi.com/1999-4923/12/2/181

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https://www.mdpi.com/1999-4923/12/2/181

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