Hypercholesterolemia and changes in lipid and bile acid metabolism in male and female cyp7A1-deficient mice

Hypercholesterolemia and changes in lipid and bile acid metabolism in male and female cyp7A1-deficient mice

Cholesterol 7α-hydroxylase, a rate-limiting enzyme for bile acid synthesis, has been implicated in genetic susceptibility to atherosclerosis. The gene, CYP7A1, encoding a protein with this activity, is expressed normally only in hepatocytes and is highly regulated. Our cyp7A1 gene knockout mouse col...

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Bibliographic Details
Main Authors: Sandra K. Erickson, Steven R. Lear, Sean Deane, Sandrine Dubrac, Sandra L. Huling, Lien Nguyen, Jaya S. Bollineni, Sarah Shefer, Hideyuki Hyogo, David E. Cohen, Benjamin Shneider, Ephraim Sehayek, Meena Ananthanarayanan, Natarajan Balasubramaniyan, Fredrick J. Suchy, Ashok K. Batta, Gerald Salen
Format: Article
Language:English
Published: Elsevier 2003-05-01
Series:Journal of Lipid Research
Subjects:
liver
intestine
lipid synthesis
low density lipoprotein receptors
sterol 27-hydroxylase
bile acid transporters
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520311469

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http://www.sciencedirect.com/science/article/pii/S0022227520311469

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