Coupling the recombineering to Cre-lox system enables simplified large-scale genome deletion in Lactobacillus casei

Coupling the recombineering to Cre-lox system enables simplified large-scale genome deletion in Lactobacillus casei

Abstract Background Lactobacillus casei is widely used in the dairy and pharmaceutical industries and a promising candidate for use as cell factories. Recently, genome sequencing and functional genomics provide the possibility for reducing L. casei genome. However, it was still limited by the ineffi...

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Bibliographic Details
Main Authors: Yongping Xin, Tingting Guo, Yingli Mu, Jian Kong
Format: Article
Language:English
Published: BMC 2018-02-01
Series:Microbial Cell Factories
Subjects:
Lactobacillus casei
Large-scale genome deletion, genome engineering
Recombineering
Cre-lox system
Online Access:http://link.springer.com/article/10.1186/s12934-018-0872-4

Internet

http://link.springer.com/article/10.1186/s12934-018-0872-4

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