Targeting of a Conserved Epitope in Mouse and Human GPVI Differently Affects Receptor Function

Targeting of a Conserved Epitope in Mouse and Human GPVI Differently Affects Receptor Function

Glycoprotein (GP) VI is the major platelet collagen receptor and a promising anti-thrombotic target. This was first demonstrated in mice using the rat monoclonal antibody JAQ1, which completely blocks the Collagen-Related Peptide (CRP)-binding site on mouse GPVI and efficiently inhibits mouse platel...

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Bibliographic Details
Main Authors: Stefano Navarro, Andreas Starke, Johan W. M. Heemskerk, Marijke J. E. Kuijpers, David Stegner, Bernhard Nieswandt
Format: Article
Language:English
Published: MDPI AG 2022-08-01
Series:International Journal of Molecular Sciences
Subjects:
glycoprotein VI
JAQ1
platelet receptors
platelet activation
platelet inhibition
Online Access:https://www.mdpi.com/1422-0067/23/15/8610

Internet

https://www.mdpi.com/1422-0067/23/15/8610

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