Primary phagocytosis of neurons by inflamed microglia: potential roles in neurodegeneration
Microglial phagocytosis of dead or dying neurons can be beneficial by preventing secondary necrosis and release of pro-inflammatory intracellular components. However, there is now evidence that under certain conditions microglia can also phagocytose viable neurons, thus executing their death. In par...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2012-02-01
|
| Series: | Frontiers in Pharmacology |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fphar.2012.00027/full |
| _version_ | 1818484519415578624 |
|---|---|
| author | Jonas J Neher Urte eNeniskyte Guy C Brown |
| author_facet | Jonas J Neher Urte eNeniskyte Guy C Brown |
| author_sort | Jonas J Neher |
| collection | DOAJ |
| description | Microglial phagocytosis of dead or dying neurons can be beneficial by preventing secondary necrosis and release of pro-inflammatory intracellular components. However, there is now evidence that under certain conditions microglia can also phagocytose viable neurons, thus executing their death. In particular, microglia eliminate synapses and neurons during development, but they also kill neurons through phagocytosis during neuroinflammation in the mature brain. Neuroinflammation accompanies many neurodegenerative diseases, such as Alzheimer’s Disease, Parkinson’s Disease, Frontotemporal Dementia and Multiple Sclerosis. In this review, we discuss the evidence supporting a role for primary phagocytosis in neurodegeneration and outline the mechanisms of this process. |
| first_indexed | 2024-12-10T15:56:38Z |
| format | Article |
| id | doaj.art-b18f3e4f6d9a4722aeed59e96f0be881 |
| institution | Directory Open Access Journal |
| issn | 1663-9812 |
| language | English |
| last_indexed | 2024-12-10T15:56:38Z |
| publishDate | 2012-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj.art-b18f3e4f6d9a4722aeed59e96f0be8812022-12-22T01:42:37ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122012-02-01310.3389/fphar.2012.0002719364Primary phagocytosis of neurons by inflamed microglia: potential roles in neurodegenerationJonas J Neher0Urte eNeniskyte1Guy C Brown2University of CambridgeUniversity of CambridgeUniversity of CambridgeMicroglial phagocytosis of dead or dying neurons can be beneficial by preventing secondary necrosis and release of pro-inflammatory intracellular components. However, there is now evidence that under certain conditions microglia can also phagocytose viable neurons, thus executing their death. In particular, microglia eliminate synapses and neurons during development, but they also kill neurons through phagocytosis during neuroinflammation in the mature brain. Neuroinflammation accompanies many neurodegenerative diseases, such as Alzheimer’s Disease, Parkinson’s Disease, Frontotemporal Dementia and Multiple Sclerosis. In this review, we discuss the evidence supporting a role for primary phagocytosis in neurodegeneration and outline the mechanisms of this process.http://journal.frontiersin.org/Journal/10.3389/fphar.2012.00027/fullInflammationMicrogliaPhagocytosisneurodegenerationlactadherinMFG-E8 |
| spellingShingle | Jonas J Neher Urte eNeniskyte Guy C Brown Primary phagocytosis of neurons by inflamed microglia: potential roles in neurodegeneration Frontiers in Pharmacology Inflammation Microglia Phagocytosis neurodegeneration lactadherin MFG-E8 |
| title | Primary phagocytosis of neurons by inflamed microglia: potential roles in neurodegeneration |
| title_full | Primary phagocytosis of neurons by inflamed microglia: potential roles in neurodegeneration |
| title_fullStr | Primary phagocytosis of neurons by inflamed microglia: potential roles in neurodegeneration |
| title_full_unstemmed | Primary phagocytosis of neurons by inflamed microglia: potential roles in neurodegeneration |
| title_short | Primary phagocytosis of neurons by inflamed microglia: potential roles in neurodegeneration |
| title_sort | primary phagocytosis of neurons by inflamed microglia potential roles in neurodegeneration |
| topic | Inflammation Microglia Phagocytosis neurodegeneration lactadherin MFG-E8 |
| url | http://journal.frontiersin.org/Journal/10.3389/fphar.2012.00027/full |
| work_keys_str_mv | AT jonasjneher primaryphagocytosisofneuronsbyinflamedmicrogliapotentialrolesinneurodegeneration AT urteeneniskyte primaryphagocytosisofneuronsbyinflamedmicrogliapotentialrolesinneurodegeneration AT guycbrown primaryphagocytosisofneuronsbyinflamedmicrogliapotentialrolesinneurodegeneration |