Black bean (Phaseolus vulgaris L.) protein hydrolysates reduce acute postprandial glucose levels in adults with prediabetes and normal glucose tolerance
This study evaluated the acute effect of black bean protein hydrolysate (BPH) on postprandial glucose and insulin levels in adults with normal glucose tolerance (NGT) or prediabetes. First, an in silico predictive digestion was performed on twenty peptides identified in BPH. Then, 28 adults with NGT...
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| Format: | Article |
| Language: | English |
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Elsevier
2024-01-01
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| Series: | Journal of Functional Foods |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1756464623005273 |
| _version_ | 1797356152239947776 |
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| author | Luis Mojica Andrea Susana Ramos-Lopez Oscar Abel Sánchez-Velázquez Armando Gómez-Ojeda Claudia Luevano-Contreras |
| author_facet | Luis Mojica Andrea Susana Ramos-Lopez Oscar Abel Sánchez-Velázquez Armando Gómez-Ojeda Claudia Luevano-Contreras |
| author_sort | Luis Mojica |
| collection | DOAJ |
| description | This study evaluated the acute effect of black bean protein hydrolysate (BPH) on postprandial glucose and insulin levels in adults with normal glucose tolerance (NGT) or prediabetes. First, an in silico predictive digestion was performed on twenty peptides identified in BPH. Then, 28 adults with NGT or prediabetes were randomized to a parallel double-blind, placebo-controlled trial. Following consent, participants were randomly assigned to one of two groups, placebo, or 5 g of BPH. To evaluate the acute effects of BPH, an oral glucose tolerance test was administered, and blood samples were collected at 60, 120, and 150 min. In the 5 g BPH group, the area under the curve for glucose, and glucose levels at 120 min were statistically lower compared to the placebo group (p = 0.04, p = 0.02). In this study, BPH had an acute glucose lowering effect after an oral glucose tolerance test in subjects with NGT or prediabetes. |
| first_indexed | 2024-03-08T14:22:31Z |
| format | Article |
| id | doaj.art-b191bdd122b543c391c861893de25dff |
| institution | Directory Open Access Journal |
| issn | 1756-4646 |
| language | English |
| last_indexed | 2024-03-08T14:22:31Z |
| publishDate | 2024-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Functional Foods |
| spelling | doaj.art-b191bdd122b543c391c861893de25dff2024-01-14T05:37:11ZengElsevierJournal of Functional Foods1756-46462024-01-01112105927Black bean (Phaseolus vulgaris L.) protein hydrolysates reduce acute postprandial glucose levels in adults with prediabetes and normal glucose toleranceLuis Mojica0Andrea Susana Ramos-Lopez1Oscar Abel Sánchez-Velázquez2Armando Gómez-Ojeda3Claudia Luevano-Contreras4Tecnología Alimentaria, Centro de Investigación y Asistencia en Tecnología y Diseño del Estado de Jalisco, A. C., CIATEJ, 44270 Guadalajara, MexicoDepartment of Medical Sciences, University of Guanajuato, Campus León, MexicoTecnología Alimentaria, Centro de Investigación y Asistencia en Tecnología y Diseño del Estado de Jalisco, A. C., CIATEJ, 44270 Guadalajara, MexicoDepartment of Medical Sciences, University of Guanajuato, Campus León, MexicoDepartment of Medical Sciences, University of Guanajuato, Campus León, Mexico; Corresponding author at: 929 20 de Enero, León, Guanajuato 37320, Mexico.This study evaluated the acute effect of black bean protein hydrolysate (BPH) on postprandial glucose and insulin levels in adults with normal glucose tolerance (NGT) or prediabetes. First, an in silico predictive digestion was performed on twenty peptides identified in BPH. Then, 28 adults with NGT or prediabetes were randomized to a parallel double-blind, placebo-controlled trial. Following consent, participants were randomly assigned to one of two groups, placebo, or 5 g of BPH. To evaluate the acute effects of BPH, an oral glucose tolerance test was administered, and blood samples were collected at 60, 120, and 150 min. In the 5 g BPH group, the area under the curve for glucose, and glucose levels at 120 min were statistically lower compared to the placebo group (p = 0.04, p = 0.02). In this study, BPH had an acute glucose lowering effect after an oral glucose tolerance test in subjects with NGT or prediabetes.http://www.sciencedirect.com/science/article/pii/S1756464623005273Black beanProtein hydrolysatesPrediabetesBioactive peptidesIn silico predictive digestion |
| spellingShingle | Luis Mojica Andrea Susana Ramos-Lopez Oscar Abel Sánchez-Velázquez Armando Gómez-Ojeda Claudia Luevano-Contreras Black bean (Phaseolus vulgaris L.) protein hydrolysates reduce acute postprandial glucose levels in adults with prediabetes and normal glucose tolerance Journal of Functional Foods Black bean Protein hydrolysates Prediabetes Bioactive peptides In silico predictive digestion |
| title | Black bean (Phaseolus vulgaris L.) protein hydrolysates reduce acute postprandial glucose levels in adults with prediabetes and normal glucose tolerance |
| title_full | Black bean (Phaseolus vulgaris L.) protein hydrolysates reduce acute postprandial glucose levels in adults with prediabetes and normal glucose tolerance |
| title_fullStr | Black bean (Phaseolus vulgaris L.) protein hydrolysates reduce acute postprandial glucose levels in adults with prediabetes and normal glucose tolerance |
| title_full_unstemmed | Black bean (Phaseolus vulgaris L.) protein hydrolysates reduce acute postprandial glucose levels in adults with prediabetes and normal glucose tolerance |
| title_short | Black bean (Phaseolus vulgaris L.) protein hydrolysates reduce acute postprandial glucose levels in adults with prediabetes and normal glucose tolerance |
| title_sort | black bean phaseolus vulgaris l protein hydrolysates reduce acute postprandial glucose levels in adults with prediabetes and normal glucose tolerance |
| topic | Black bean Protein hydrolysates Prediabetes Bioactive peptides In silico predictive digestion |
| url | http://www.sciencedirect.com/science/article/pii/S1756464623005273 |
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