Exosomal miRNAs from Prostate Cancer Impair Osteoblast Function in Mice

Exosomal miRNAs from Prostate Cancer Impair Osteoblast Function in Mice

Prostate cancer (PCa) is the most frequent malignancy in older men with a high propensity for bone metastases. Characteristically, PCa causes osteosclerotic lesions as a result of disrupted bone remodeling. Extracellular vesicles (EVs) participate in PCa progression by conditioning the pre-metastati...

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Bibliographic Details
Main Authors: Giulia Furesi, Antonio Miguel de Jesus Domingues, Dimitra Alexopoulou, Andreas Dahl, Matthias Hackl, Johannes R. Schmidt, Stefan Kalkhof, Thomas Kurth, Hanna Taipaleenmäki, Stefanie Conrad, Christine Hofbauer, Martina Rauner, Lorenz C. Hofbauer
Format: Article
Language:English
Published: MDPI AG 2022-01-01
Series:International Journal of Molecular Sciences
Subjects:
bone metastases
prostate cancer
osteoprogenitors
extracellular vesicles
miRNA
Online Access:https://www.mdpi.com/1422-0067/23/3/1285

Internet

https://www.mdpi.com/1422-0067/23/3/1285

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