Astragaloside IV Inhibits NLRP3 Inflammasome-Mediated Pyroptosis via Activation of Nrf-2/HO-1 Signaling Pathway and Protects against Doxorubicin-Induced Cardiac Dysfunction

Astragaloside IV Inhibits NLRP3 Inflammasome-Mediated Pyroptosis via Activation of Nrf-2/HO-1 Signaling Pathway and Protects against Doxorubicin-Induced Cardiac Dysfunction

Background: Doxorubicin (DOX) is an effective broad-spectrum antitumor drug, but its clinical application is limited due to the side effects of cardiac damage. Astragaloside IV (AS-IV) is a significant active component of Astragalus membranaceus that exerts cardioprotective effects through various p...

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Bibliographic Details
Main Authors: Xueheng Chen, Chao Tian, Zhiqiang Zhang, Yiran Qin, Runqi Meng, Xuening Dai, Yuanyuan Zhong, Xiqing Wei, Jinguo Zhang, Cheng Shen
Format: Article
Language:English
Published: IMR Press 2023-03-01
Series:Frontiers in Bioscience-Landmark
Subjects:
astragalus membranaceus
doxorubicin
pyroptosis
nrf-2/ho-1
cardiac dysfunction
cardioprotection
Online Access:https://www.imrpress.com/journal/FBL/28/3/10.31083/j.fbl2803045

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https://www.imrpress.com/journal/FBL/28/3/10.31083/j.fbl2803045

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