Does receptor balance matter? – Comparing the efficacies of the dual amylin and calcitonin receptor agonists cagrilintide and KBP-336 on metabolic parameters in preclinical models

Does receptor balance matter? – Comparing the efficacies of the dual amylin and calcitonin receptor agonists cagrilintide and KBP-336 on metabolic parameters in preclinical models

Cagrilintide is a novel long-acting amylin receptor agonist, which has shown a potent induction of weight loss. Interestingly, cagrilintide is a Dual Amylin and Calcitonin Receptor Agonist (DACRA) derived from an amylin backbone. Another class of long-acting DACRAs exists, namely the KBPs. These are...

Full description

Bibliographic Details
Main Authors: A.T. Larsen, K.E. Mohamed, N. Sonne, E. Bredtoft, F. Andersen, MA Karsdal, K. Henriksen
Format: Article
Language:English
Published: Elsevier 2022-12-01
Series:Biomedicine & Pharmacotherapy
Subjects:
DACRA
Once-weekly
Obesity
T2D
Pre-clinical
Online Access:http://www.sciencedirect.com/science/article/pii/S0753332222012318

Internet

http://www.sciencedirect.com/science/article/pii/S0753332222012318

Similar Items