Spermidine supplementation in rare translation-associated disorders

The polyamine spermidine is essential for protein translation in eukaryotes, both as a substrate for the hypusination of the translation initiation factor eIF5A as well as general translational fidelity. Dwindling spermidine levels during aging have been implicated in reduced immune cell function th...

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Bibliographic Details
Main Authors: Andreas Zimmermann, Didac Carmona-Gutierrez, Frank Madeo
Format: Article
Language:English
Published: Shared Science Publishers OG 2021-03-01
Series:Cell Stress
Subjects:
Online Access:http://www.cell-stress.com/researcharticles/2021a-zimmermann-cell-stress/