Impact of mAb-induced A475V substitution on viral fitness and antibody neutralization of SARS-CoV-2 omicron variants in the presence of monoclonal antibodies and human convalescent sera

Impact of mAb-induced A475V substitution on viral fitness and antibody neutralization of SARS-CoV-2 omicron variants in the presence of monoclonal antibodies and human convalescent sera

The emergence and rapid evolution of SARS-CoV-2 variants have posed a major challenge to the global efforts to control the COVID -19 pandemic. In this study, we investigated the potential of two SARS-CoV-2 variants, BA.2 and BA.5, to evade neutralization by a human monoclonal antibody targeting the...

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Bibliographic Details
Main Authors: Ratchanont Viriyakitkosol, Asawin Wanitchang, Kanjana Srisutthisamphan, Janya Saenboonreung, Chatikorn Boonkrai, Trairak Pisitkun, Anan Jongkaewwattana
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-08-01
Series:Frontiers in Immunology
Subjects:
SARS-CoV-2
monoclonal antibodies
antibody resistance
A475V
viral fitness
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1219546/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2023.1219546/full

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