An amber obligate active site-directed ligand evolution technique for phage display

An amber obligate active site-directed ligand evolution technique for phage display

Most epigenetic regulator inhibitors target tunnels of active sites, rather than the peptide binding groove, leading to concerns with low selectivity. Here the authors use an amber obligate phage library to rapidly identify isoform-selective inhibitors of SIRT2.

Bibliographic Details
Main Authors: Jeffery M. Tharp, J. Trae Hampton, Catrina A. Reed, Andreas Ehnbom, Peng-Hsun Chase Chen, Jared S. Morse, Yadagirri Kurra, Lisa M. Pérez, Shiqing Xu, Wenshe Ray Liu
Format: Article
Language:English
Published: Nature Portfolio 2020-03-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-020-15057-7

Internet

https://doi.org/10.1038/s41467-020-15057-7

Similar Items