Down Syndrome Altered Cell Composition in Blood, Brain, and Buccal Swab Samples Profiled by DNA-Methylation-Based Cell-Type Deconvolution

Down Syndrome Altered Cell Composition in Blood, Brain, and Buccal Swab Samples Profiled by DNA-Methylation-Based Cell-Type Deconvolution

Down syndrome (DS) is a genetic disorder caused by an extra copy of chromosome 21 that presents developmental dysfunction and intellectual disability. To better understand the cellular changes associated with DS, we investigated the cell composition in blood, brain, and buccal swab samples from DS p...

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Bibliographic Details
Main Authors: Ze Zhang, Hannah G. Stolrow, Brock C. Christensen, Lucas A. Salas
Format: Article
Language:English
Published: MDPI AG 2023-04-01
Series:Cells
Subjects:
down syndrome
trisomy 21
DNA methylation
cell deconvolution
epigenetics
immune cell deconvolution
Online Access:https://www.mdpi.com/2073-4409/12/8/1168

Internet

https://www.mdpi.com/2073-4409/12/8/1168

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