Ribosomal Protein S6 Hypofunction in Postmortem Human Brain Links mTORC1-Dependent Signaling and Schizophrenia

Ribosomal Protein S6 Hypofunction in Postmortem Human Brain Links mTORC1-Dependent Signaling and Schizophrenia

The mechanistic target of rapamycin (also known as mammalian target of rapamycin) (mTOR)-dependent signaling pathway plays an important role in protein synthesis, cell growth, and proliferation, and has been linked to the development of the central nervous system. Recent studies suggest that mTOR si...

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Bibliographic Details
Main Authors: Inés Ibarra-Lecue, Rebeca Diez-Alarcia, Benito Morentin, J. Javier Meana, Luis F. Callado, Leyre Urigüen
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-03-01
Series:Frontiers in Pharmacology
Subjects:
ribosomal protein S6
schizophrenia
mTORC1
postmortem tissue
antipsychotics
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2020.00344/full

Internet

https://www.frontiersin.org/article/10.3389/fphar.2020.00344/full

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