Delineating the role of c-FLIP/NEMO interaction in the CD95 network via rational design of molecular probes

Delineating the role of c-FLIP/NEMO interaction in the CD95 network via rational design of molecular probes

Abstract Background Structural homology modeling supported by bioinformatics analysis plays a key role in uncovering new molecular interactions within gene regulatory networks. Here, we have applied this powerful approach to analyze the molecular interactions orchestrating death receptor signaling n...

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Bibliographic Details
Main Authors: Nikita V. Ivanisenko, Jörn H. Buchbinder, Johannes Espe, Max Richter, Miriam Bollmann, Laura K. Hillert, Vladimir A. Ivanisenko, Inna N. Lavrik
Format: Article
Language:English
Published: BMC 2019-05-01
Series:BMC Genomics
Subjects:
In silico
Homology modeling
Death receptor network
Evolutionary conservation
C-FLIP
V-FLIP
Online Access:http://link.springer.com/article/10.1186/s12864-019-5539-y

Internet

http://link.springer.com/article/10.1186/s12864-019-5539-y

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