Platinum complexes of curcumin delivered by dual-responsive polymeric nanoparticles improve chemotherapeutic efficacy based on the enhanced anti-metastasis activity and reduce side effects

Platinum complexes of curcumin delivered by dual-responsive polymeric nanoparticles improve chemotherapeutic efficacy based on the enhanced anti-metastasis activity and reduce side effects

Platinum-based chemotherapy is used for non-small cell lung cancer (NSCLC). However, it has side effects and minimum efficacy against lung cancer metastasis. In this study, platinum–curcumin complexes were loaded into pH and redox dual-responsive nanoparticles (denoted as Pt–CUR@PSPPN) to facilitate...

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Bibliographic Details
Main Authors: Yan Chen, Chen Chen, Xiaojuan Zhang, Chuanchuan He, Pengxuan Zhao, Minsi Li, Ting Fan, Ruicong Yan, Yao Lu, Robert J. Lee, Muhammad Waseem Khan, Muhammad Sarfraz, Xiang Ma, Tan Yang, Guangya Xiang
Format: Article
Language:English
Published: Elsevier 2020-06-01
Series:Acta Pharmaceutica Sinica B
Subjects:
Platinum
Curcumin
Complex
Nanoparticles
Non-small cell lung cancer
Anti-metastasis
Online Access:http://www.sciencedirect.com/science/article/pii/S2211383519309931

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http://www.sciencedirect.com/science/article/pii/S2211383519309931

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