Analysis of Biotinylated Generation 4 Poly(amidoamine) (PAMAM) Dendrimer Distribution in the Rat Brain and Toxicity in a Cellular Model of the Blood-Brain Barrier

Analysis of Biotinylated Generation 4 Poly(amidoamine) (PAMAM) Dendrimer Distribution in the Rat Brain and Toxicity in a Cellular Model of the Blood-Brain Barrier

Dendrimers are highly customizable nanopolymers with qualities that make them ideal for drug delivery. The high binding affinity of biotin/avidin provides a useful approach to fluorescently label synthesized dendrimer-conjugates in cells and tissues. In addition, biotin may facilitate delivery of de...

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Bibliographic Details
Main Authors: Heather A. Bullen, Kristi L. Haik, Celeste Morris, Steven Wall, Anthony Haskamp, Megan Caroway, Michael Hester, Robert Spaulding, Brett Rossow, Ruth Hemmer, Andrew Hall
Format: Article
Language:English
Published: MDPI AG 2013-09-01
Series:Molecules
Subjects:
dendrimers
atomic force microscopy
fluorescence microscopy
biotin
toxicity
blood brain barrier
lactate dehydrogenase assay
Online Access:http://www.mdpi.com/1420-3049/18/9/11537

Internet

http://www.mdpi.com/1420-3049/18/9/11537

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