A Serological Neoepitope Biomarker of Neutrophil Elastase-Degraded Calprotectin, Associated with Neutrophil Activity, Identifies Idiopathic Pulmonary Fibrosis and Chronic Obstructive Pulmonary Disease More Effectively Than Total Calprotectin

A Serological Neoepitope Biomarker of Neutrophil Elastase-Degraded Calprotectin, Associated with Neutrophil Activity, Identifies Idiopathic Pulmonary Fibrosis and Chronic Obstructive Pulmonary Disease More Effectively Than Total Calprotectin

Neutrophil activation can release neutrophil extracellular traps (NETs) in acute inflammation. NETs result in the release of human neutrophil elastase (HNE) and calprotectin, where the former can degrade the latter and generate protein fragments associated with neutrophil activity. We investigated t...

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Bibliographic Details
Main Authors: Annika Hummersgaard Hansen, Joachim Høg Mortensen, Sarah Rank Rønnow, Morten Asser Karsdal, Diana Julie Leeming, Jannie Marie Bülow Sand
Format: Article
Language:English
Published: MDPI AG 2023-12-01
Series:Journal of Clinical Medicine
Subjects:
biomarker
neoepitope
neutrophil activity
IPF
COPD
calprotectin
Online Access:https://www.mdpi.com/2077-0383/12/24/7589

Internet

https://www.mdpi.com/2077-0383/12/24/7589

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