Extracellular Vesicles from Human Teeth Stem Cells Trigger ATP Release and Promote Migration of Human Microglia through P2X4 Receptor/MFG-E8-Dependent Mechanisms

Extracellular Vesicles from Human Teeth Stem Cells Trigger ATP Release and Promote Migration of Human Microglia through P2X4 Receptor/MFG-E8-Dependent Mechanisms

Extracellular vesicles (EVs) effectively suppress neuroinflammation and induce neuroprotective effects in different disease models. However, the mechanisms by which EVs regulate the neuroinflammatory response of microglia remains largely unexplored. Here, we addressed this issue by testing the actio...

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Bibliographic Details
Main Authors: Ugnė Jonavičė, Diana Romenskaja, Karolina Kriaučiūnaitė, Akvilė Jarmalavičiūtė, Justina Pajarskienė, Vytautas Kašėta, Virginijus Tunaitis, Tarja Malm, Rashid Giniatullin, Augustas Pivoriūnas
Format: Article
Language:English
Published: MDPI AG 2021-10-01
Series:International Journal of Molecular Sciences
Subjects:
microglia
extracellular vesicles
migration
ATP
P2X4 receptor
MFG-E8
Online Access:https://www.mdpi.com/1422-0067/22/20/10970

Internet

https://www.mdpi.com/1422-0067/22/20/10970

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