Multi‐omic analysis in normal colon organoids highlights MSH4 as a novel marker of defective mismatch repair in Lynch syndrome and microsatellite instability

Multi‐omic analysis in normal colon organoids highlights MSH4 as a novel marker of defective mismatch repair in Lynch syndrome and microsatellite instability

Abstract Introduction Lynch syndrome (LS) is a hereditary condition that increases the risk of colorectal (CRC) and extracolonic cancers that exhibit microsatellite instability (MSI‐H). MSI‐H is driven by defective mismatch repair (dMMR), and approximately 15% of nonhereditary CRCs also exhibit MSI‐...

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Bibliographic Details
Main Authors: Matthew Devall, Mourad W. Ali, Stephen Eaton, Daniel J. Weisenberger, Matthew J. Reilley, Steven M. Powell, Li Li, Graham Casey
Format: Article
Language:English
Published: Wiley 2023-06-01
Series:Cancer Medicine
Subjects:
colon organoids
colorectal cancer
Lynch syndrome
microsatellite instability
Online Access:https://doi.org/10.1002/cam4.6048

Internet

https://doi.org/10.1002/cam4.6048

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