Mouse Gut Microbiome-Encoded β-Glucuronidases Identified Using Metagenome Analysis Guided by Protein Structure

Mouse Gut Microbiome-Encoded β-Glucuronidases Identified Using Metagenome Analysis Guided by Protein Structure

ABSTRACT Gut microbial β-glucuronidase (GUS) enzymes play important roles in drug efficacy and toxicity, intestinal carcinogenesis, and mammalian-microbial symbiosis. Recently, the first catalog of human gut GUS proteins was provided for the Human Microbiome Project stool sample database and reveale...

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Bibliographic Details
Main Authors: Benjamin C. Creekmore, Josh H. Gray, William G. Walton, Kristen A. Biernat, Michael S. Little, Yongmei Xu, Jian Liu, Raad Z. Gharaibeh, Matthew R. Redinbo
Format: Article
Language:English
Published: American Society for Microbiology 2019-08-01
Series:mSystems
Subjects:
beta-glucuronidase
gut microbiome
mouse metagenomics
protein structure-function
Online Access:https://journals.asm.org/doi/10.1128/mSystems.00452-19

Internet

https://journals.asm.org/doi/10.1128/mSystems.00452-19

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