Bone tumor-homing nanotherapeutics for prolonged retention in tumor microenvironment and facilitated apoptotic process via mevalonate pathway inhibition

Bone tumor-homing nanotherapeutics for prolonged retention in tumor microenvironment and facilitated apoptotic process via mevalonate pathway inhibition

Bone malignancy features a mineralized extracellular matrix primarily composed of hydroxyapatite, which interferes with the distribution and activity of antineoplastic agents. Herein, we report bone tumor-homing polymeric nanotherapeutics consisting of alendronate-decorated chondroitin sulfate A-gra...

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Bibliographic Details
Main Authors: Nae-Won Kang, Voradanu Visetvichaporn, Duy-Thuc Nguyen, Eun Kyung Shin, Dahan Kim, Min-Jae Kim, So-Yeol Yoo, Jae-Young Lee, Dae-Duk Kim
Format: Article
Language:English
Published: Elsevier 2023-04-01
Series:Materials Today Bio
Subjects:
Bone tumors
Alendronate
Mevalonate pathway inhibition
Hydroxyapatites
Tumor distribution
Apoptosis
Online Access:http://www.sciencedirect.com/science/article/pii/S2590006423000510

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http://www.sciencedirect.com/science/article/pii/S2590006423000510

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