High Frequency Mutations in pfdhfr and pfdhps of Plasmodium falciparum in Response to Sulfadoxine-Pyrimethamine: A Cross-Sectional Survey in Returning Chinese Migrants From Africa

High Frequency Mutations in pfdhfr and pfdhps of Plasmodium falciparum in Response to Sulfadoxine-Pyrimethamine: A Cross-Sectional Survey in Returning Chinese Migrants From Africa

BackgroundSulfadoxine-pyrimethamine (SP) is recommended for intermittent preventive treatment in Africa against Plasmodium falciparum infection. However, increasing SP resistance (SPR) of P. falciparum affects the therapeutic efficacy of SP, and pfdhfr (encoding dihydrofolate reductase) and pfdhps (...

Full description

Bibliographic Details
Main Authors: He Yan, Jun Feng, Jian-hai Yin, Fang Huang, Xiang-li Kong, Kang-ming Lin, Tao Zhang, Xin-yu Feng, Shui-sen Zhou, Jian-ping Cao, Zhi-gui Xia
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-09-01
Series:Frontiers in Cellular and Infection Microbiology
Subjects:
Plasmodium falciparum
sulfadoxine-pyrimethamine
dihydropteroate synthase
dihydrofolate reductase
migrants from Africa
Online Access:https://www.frontiersin.org/articles/10.3389/fcimb.2021.673194/full

Internet

https://www.frontiersin.org/articles/10.3389/fcimb.2021.673194/full

Similar Items