PEGylated Domain I of Beta-2-Glycoprotein I Inhibits Thrombosis in a Chronic Mouse Model of the Antiphospholipid Syndrome

PEGylated Domain I of Beta-2-Glycoprotein I Inhibits Thrombosis in a Chronic Mouse Model of the Antiphospholipid Syndrome

Antiphospholipid syndrome (APS) is an autoimmune disorder in which autoantibodies cause clinical effects of vascular thrombosis and pregnancy morbidity. The only evidence-based treatments are anticoagulant medications such as warfarin and heparin. These medications have a number of disadvantages, no...

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Bibliographic Details
Main Authors: Rohan Willis, Thomas C. R. McDonnell, Charis Pericleous, Emilio B. Gonzalez, Alvaro Schleh, Zurina Romay-Penabad, Ian P. Giles, Anisur Rahman
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-04-01
Series:Frontiers in Immunology
Subjects:
antiphospholipid syndrome
beta-2-glycoprotein I
PEGylation
domain I
thrombosis
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.842923/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2022.842923/full

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