Gene Profiling of a 3D Psoriatic Skin Model Enriched in T Cells: Downregulation of <i>PTPRM</i> Promotes Keratinocyte Proliferation through Excessive ERK1/2 Signaling

Gene Profiling of a 3D Psoriatic Skin Model Enriched in T Cells: Downregulation of <i>PTPRM</i> Promotes Keratinocyte Proliferation through Excessive ERK1/2 Signaling

Psoriasis is a complex, immune-mediated skin disease involving a wide range of epithelial and immune cells. The underlying mechanisms that govern the epidermal defects and immunological dysfunction observed in this condition remain largely unknown. In recent years, the emergence of new, more sophist...

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Bibliographic Details
Main Authors: Geneviève Rioux, Florence Turgeon, Gaëtan Le-Bel, Camille Grenier, Sylvain L. Guérin, Roxane Pouliot
Format: Article
Language:English
Published: MDPI AG 2022-09-01
Series:Cells
Subjects:
psoriasis
tissue-engineered skin
ERK1/2
PTPRM
transcriptome
keratinocytes
Online Access:https://www.mdpi.com/2073-4409/11/18/2904

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