Novel AT2R agonist, β-Pro7Ang III, is cardio- and vaso-protective in diabetic spontaneously hypertensive rats

Novel AT2R agonist, β-Pro7Ang III, is cardio- and vaso-protective in diabetic spontaneously hypertensive rats

Stimulation of the angiotensin II type 2 receptor (AT2R) evokes protective effects in various cardiovascular diseases. Thus, this study aimed to investigate the effects of AT2R stimulation, with or without AT1R blockade, in a model of hypertension with concomitant type 1 diabetes mellitus (T1DM). Sp...

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Bibliographic Details
Main Authors: Mandy Li, Levi Nguyen, Dorota Ferens, Iresha Spizzo, Yan Wang, Kate M. Denton, Mark Del Borgo, Ketav Kulkarni, Marie-Isabel Aguilar, Chengxue Helena Qin, Chrishan S. Samuel, Tracey A. Gaspari, Robert E. Widdop
Format: Article
Language:English
Published: Elsevier 2023-09-01
Series:Biomedicine & Pharmacotherapy
Subjects:
Hypertension
Diabetes
Renin-angiotensin system
Angiotensin II type 2 receptor (AT2R)
Fibrosis
Inflammation
Online Access:http://www.sciencedirect.com/science/article/pii/S0753332223010296

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http://www.sciencedirect.com/science/article/pii/S0753332223010296

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