Fermentative Production of N-Alkylated Glycine Derivatives by Recombinant Corynebacterium glutamicum Using a Mutant of Imine Reductase DpkA From Pseudomonas putida

Fermentative Production of N-Alkylated Glycine Derivatives by Recombinant Corynebacterium glutamicum Using a Mutant of Imine Reductase DpkA From Pseudomonas putida

Sarcosine, an N-methylated amino acid, shows potential as antipsychotic, and serves as building block for peptide-based drugs, and acts as detergent when acetylated. N-methylated amino acids are mainly produced chemically or by biocatalysis, with either low yields or high costs for co-factor regener...

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Bibliographic Details
Main Authors: Melanie Mindt, Silvin Hannibal, Maria Heuser, Joe Max Risse, Keerthi Sasikumar, K. Madhavan Nampoothiri, Volker F. Wendisch
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-09-01
Series:Frontiers in Bioengineering and Biotechnology
Subjects:
Corynebacterium glutamicum
imine reductase
metabolic engineering
enzyme engineering
N-alkylated amino acids
N-methylamino acids
Online Access:https://www.frontiersin.org/article/10.3389/fbioe.2019.00232/full

Internet

https://www.frontiersin.org/article/10.3389/fbioe.2019.00232/full

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