Targeted next-generation sequencing and long-read HiFi sequencing provide novel insights into clinically significant KLF1 variants

Targeted next-generation sequencing and long-read HiFi sequencing provide novel insights into clinically significant KLF1 variants

Abstract Background Krüppel-like factor 1 (KLF1), a crucial erythroid transcription factor, plays a significant role in various erythroid changes and haemolytic diseases. The rare erythrocyte Lutheran inhibitor (In(Lu)) blood group phenotype serves as an effective model for identifying KLF1 hypomorp...

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Bibliographic Details
Main Authors: Luyi Ye, Chen Wang, Aijing Li, Minghao Li, Yan Pi, Jingmin Yang, Ziyan Zhu, Daru Lu
Format: Article
Language:English
Published: BMC 2024-03-01
Series:BMC Genomics
Subjects:
KLF1
In(Lu) phenotype
LU blood group
NGS
HiFi sequencing
Online Access:https://doi.org/10.1186/s12864-024-10148-x

Internet

https://doi.org/10.1186/s12864-024-10148-x

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