Topical application of calcitonin gene-related peptide as a regenerative, antifibrotic, and immunomodulatory therapy for corneal injury

Topical application of calcitonin gene-related peptide as a regenerative, antifibrotic, and immunomodulatory therapy for corneal injury

Abstract Calcitonin gene-related peptide (CGRP) is a multifunctional neuropeptide abundantly expressed by corneal nerves. Using a murine model of corneal mechanical injury, we found CGRP levels in the cornea significantly reduced after injury. Topical application of CGRP as an eye drop accelerates c...

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Bibliographic Details
Main Authors: Asmaa A. Zidan, Shuyan Zhu, Elsayed Elbasiony, Sheyda Najafi, Zhirong Lin, Rohan Bir Singh, Amirreza Naderi, Jia Yin
Format: Article
Language:English
Published: Nature Portfolio 2024-03-01
Series:Communications Biology
Online Access:https://doi.org/10.1038/s42003-024-05934-y

Internet

https://doi.org/10.1038/s42003-024-05934-y

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