A Temperature Sensitive Variant of p53 Drives p53-Dependent MicroRNA Expression without Evidence of Widespread Post-Transcriptional Gene Silencing.

A Temperature Sensitive Variant of p53 Drives p53-Dependent MicroRNA Expression without Evidence of Widespread Post-Transcriptional Gene Silencing.

The p53 tumour suppressor is a transcription factor that can regulate the expression of numerous genes including many encoding proteins and microRNAs (miRNAs). The predominant outcomes of a typical p53 response are the initiation of apoptotic cascades and the activation of cell cycle checkpoints. HT...

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Bibliographic Details
Main Authors: Miguel A Cabrita, Erin J Vanzyl, Jeff D Hamill, Elysia Pan, Kristen A Marcellus, Victoria J Tolls, Rhea C Alonzi, Alyssa Pastic, Teeghan M E Rambo, Hadil Sayed, Bruce C McKay
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2016-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4739602?pdf=render

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http://europepmc.org/articles/PMC4739602?pdf=render

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