Elimination of GGTA1, CMAH, β4GalNT2 and CIITA genes in pigs compromises human versus pig xenogeneic immune reactions

Elimination of GGTA1, CMAH, β4GalNT2 and CIITA genes in pigs compromises human versus pig xenogeneic immune reactions

Abstract Background Pig organ xenotransplantation is a potential solution for the severe organ shortage in clinic, while immunogenic genes need to be eliminated to improve the immune compatibility between humans and pigs. Current knockout strategies are mainly aimed at the genes causing hyperacute i...

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Bibliographic Details
Main Authors: Jing Xu, Jilong Ren, Kai Xu, Minghui Fang, Meina Ka, Fei Xu, Xin Wang, Jing Wang, Zhiqiang Han, Guihai Feng, Ying Zhang, Tang Hai, Wei Li, Zheng Hu
Format: Article
Language:English
Published: Wiley 2024-08-01
Series:Animal Models and Experimental Medicine
Subjects:
CD4 T cell
genetically edited pig
immune rejection
major histocompatibility complex II
xenotransplantation
Online Access:https://doi.org/10.1002/ame2.12461

Internet

https://doi.org/10.1002/ame2.12461

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